D-Phenylalanine, 2,5-dichloro- - Names and Identifiers
Name | D-2,5-Dichlorophenylalanine
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Synonyms | H-D-Phe(2,5-DiCl)-OH D-2,5-Dichlorophenylalanine 2,5-Dichloro-D-phenylalanine D-Phenylalanine, 2,5-dichloro- (R)-2-Amino-3-(2,5-dichlorophenyl)propanoicaci (R)-2-AMino-3-(2,5-dichlorophenyl)propanoic acid (2R)-2-amino-3-(2,5-dichlorophenyl)propanoic acid (2R)-2-amino-3-(2,5-dichlorophenyl)propanoic acid hydrochloride
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CAS | 718596-54-4
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D-Phenylalanine, 2,5-dichloro- - Physico-chemical Properties
Molecular Formula | C9H9Cl2NO2
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Molar Mass | 234.08 |
Density | 1.450±0.06 g/cm3(Predicted) |
Boling Point | 365.7±42.0 °C(Predicted) |
Appearance | Solid |
pKa | 2.12±0.15(Predicted) |
Storage Condition | 2-8°C |
D-Phenylalanine, 2,5-dichloro- - Introduction
D-2,5-Dichlorophenylalanine(D-2) is a chiral amino acid divided into two enantiomers, D-and L. Among them, D-2,5-Dichlorophenylalanine is the D-enantiomer and has the following properties:
1. Appearance: white crystalline solid.
2. solubility: soluble in water, alcohol and ether solvents.
3. Melting point: about 225-230°C.
4. chemical properties: under acidic conditions will carry out photolysis reaction, the formation of amide and dichlorophenyl ether and other products.
D-2,5-Dichlorophenylalanine has important application value in the field of medicine, and is commonly used in the synthesis of new drugs, drug precursors and the preparation of polypeptide antibiotics. It can be used as an intermediate in the synthesis of chiral drugs, or for protein engineering that changes the natural amino acid sequence.
The production method thereof is generally carried out by a chemical synthesis method. Common preparation methods include:
1. D-2,5-Dichlorophenylalanine was prepared from phenylalanine by chlorination reaction, alkaline hydrolysis and other steps.
2. Using the catalyst with chiral inducer, the asymmetric chlorination reaction of phenylalanine was carried out to obtain D-2,5-Dichlorophenylalanine.
Regarding safety information, D-2, the specific toxicity data of 5-Dichlorophenylalanine is relatively small, so necessary safety measures should be taken when using it. Such as wear protective gloves, goggles and other personal protective equipment, avoid contact with skin, eyes, etc. At the same time, it should be operated in a well-ventilated place and stored properly to avoid reaction with other chemicals. In case of accidental contact or inhalation, seek medical attention immediately. During use and storage, it is necessary to operate in accordance with specific laboratory safety practices and relevant regulations.
Last Update:2024-04-09 21:11:58